When sixteen-year-old Cady Heron moves from Africa to the US, she quickly learns that social life at her new high school is run by queen bee Regina George and her mean girl crew, collectively known as The Plastics. Along with pals Damien and Janice, Cady hatches a plan to take down The Plastics from inside by infiltrating the group — a perfect plan, if only Cady can stay true to herself.
Jo Mitchell is an 18-year-old high school senior from Ohio. On her first day at North Shore High School, she encounters a clique called "The Plastics": the self-proclaimed leader, Mandi Weatherly; the ditzy girl with the raging libido, Chastity Meyer; and the Hypochondriasis Hope Plotkin. Jo also meets Abby Hanover, whom Mandi perceives to be a rival. Jo becomes attracted to Tyler Adams. Despite Jo's attempts to avoid the Plastics, conflict develops between them and Abby.