MacGruber is based on the Saturday Night Live sketch of the same name, which itself is a parody of action-adventure television series MacGyver.
In eastern Siberia's Dzhugdzhur Mountains, Dieter Von Cunth and his men take control of the X-5 missile, which has a nuclear warhead. In Ecuador, Col. Jim Faith and Lt. Dixon Piper are searching for former Special Forces (United States Army), United States Navy SEALs and United States Army Rangers MacGruber. The two men find him meditating in a chapel, and try to convince him to retrieve the warhead. MacGruber refuses; later that night, MacGruber explodes into a fit of rage after a flashback where Cunth killed his fiancée, Casey Fitzpatrick, at their wedding; he then accepts the offer.
After rotting in prison for over a decade, America's ultimate hero and uber patriot MacGruber is finally released. His mission: to take down a mysterious villain from his past—Brigadier Commander Enos Queeth. With the entire world in the crosshairs, MacGruber must reassemble his old team in order to defeat the forces of evil.