Spy extraordinaire Derek Flint (James Coburn) is an ex-agent of Z.O.W.I.E. (Zonal Organization for World Intelligence and Espionage) who is brought out of retirement to deal with the threat of ''Galaxy'', a worldwide organization led by a trio of mad scientists: Doctor Krupov (Rhys Williams (Welsh-American actor)), Doctor Wu (Peter Brocco), and Doctor Schneider (Benson Fong). Impatient that the world's governments will never improve, the scientists demand that all nations capitulate to Galaxy. To enforce their demands, they initiate earthquakes, volcanoes, storms and other natural disasters with their climate-control apparatus, for the only purpose to bring the nations to give up weapons and nuclear energy.
After observing the launch of a new space platform, Z.O.W.I.E. (Zonal Organisation World Intelligence Espionage) Chief Lloyd C. Cramden joins President Trent (Andrew Duggan) for a game of golf. While on the links they are interrupted by a small group, two women disguised as boys and an actor disguised as an old man, all from the Fabulous Face organization. Discreetly substituting the presidential golf ball with a small gas bomb they succeed in temporarily immobilizing the presidential party and replacing the president with the now-undisguised actor, who has been surgically altered to look exactly like him. The Fabulous Face organization has conceived a plot to gain control of the world and run it entirely by a group of women led by Elisabeth (Anna Lee); Cramden has more-or-less inadvertently stumbled upon this world-domination plot. The women want to establish a matriarchy, and the first step in their plan is to gain control of a US space facility in the Virgin Islands. Elisabeth has established the spa there as a cover. The women establish their headquarters near the rocket base to brainwash their male-oriented sisters by planting tape recorders in their hair dryers.