In this franchise that almost didn't happen, Ryan Reynolds stars as Wade Wilson, a former Special Forces operative who now works as a mercenary. His world comes crashing down when evil scientist Ajax tortures, disfigures and transforms him into Deadpool. The rogue experiment leaves Deadpool with accelerated healing powers and a twisted sense of humor. With help from mutant allies Colossus and Negasonic Teenage Warhead, Deadpool uses his new skills to hunt down the man who nearly destroyed his life.
A wisecracking mercenary gets experimented on and becomes immortal but ugly, and sets out to track down the man who ruined his looks.
Foul-mouthed mutant mercenary Wade Wilson (a.k.a. Deadpool), brings together a team of fellow mutant rogues to protect a young boy with supernatural abilities from the brutal, time-traveling cyborg Cable.
The film is rumored to involve another popular group in the X-Men mythos, X-Force.
After successfully working as the mercenary Deadpool for two years, Wade Wilson fails to kill one of his targets on his anniversary with Copycat (Marvel Comics), his girlfriend. That night, after the pair decide to start a family together, the target tracks Wilson down and inadvertently kills Vanessa. Wilson kills the man in revenge. He blames himself for her death and attempts to commit suicide six weeks later by blowing himself up. Wilson has a vision of Vanessa in the afterlife, but the pieces of his body remain alive and are put back together by Colossus (comics). Wilson is left with only a Skee-Ball token, an anniversary gift, as a final memento of Vanessa.
Deadpool sees an opportunity to save the day, but it doesn't go entirely as planned.