All films from the reptilian cult horror “Anaconda” franchise.
A poacher hides from an unknown creature in his boat. While it breaks through the boat and attempts to catch the poacher, he commits suicide by shooting himself dead to prevent the beast from killing him.
A team of researchers funded by a New York pharmaceutical firm Wexel Hall, including Dr. Jack Byron, Gordon Mitchell, Sam Rogers, Gail Stern, Cole Burris, and Dr. Ben Douglas leave for a jungle in Borneo - Indonesia to search for a flower called ''Perrinnia Immortalis'', which they believe can be used as a type of fountain of youth. Though their guide Captain Bill Johnson and his partner Tran Wu has misgivings about which path to take, Jack convinces him to take an unsafe path. The team goes over a waterfall and has to wade through the river. A giant anaconda emerges from the water and swallows Ben whole, but the rest of the team escape from the river. Bill assures them that it was the largest snake he has ever seen and that it should take weeks for it to grow hungry again. However, most of the team demand that the expedition be called off. They travel to Bill's friend, John Livingston, who lives on the river, to see if Bill can borrow his boat, but they find Livingston dead and his boat crashed.
In Romania, an anaconda that was captured from the Amazon River is being held at a genetic research facility owned by Wexel Hall for experimentation when Professor Eric Kane has developed a serum for the Blood Orchid (the one recovered from the fountain after the ruins of the Borneo jungle). The research project is led by Dr. Amanda Hayes and funded by Peter "J.D." Murdoch, a well-known industrialist. While visiting the facility, Murdoch provokes the anaconda with a large flashlight, and has it gassed to calm it down. However, as Murdoch, his assistant Pinkus and Daryl are about to leave, the anaconda kills Daryl and breaks through his enclosure's wall. As it escapes, it kills many of the people working in the laboratory. In looking through the facility, Amanda and the professor realize that the anaconda also freed the queen anaconda. The anaconda soon sneaks up behind them and crushes the professor to death in its coils and bites his head off. Murdoch calls in a team of animal hunters, led by Stephen Hammett to capture both snakes. Amanda and Pinkus go with them. At a small farm in the middle of the woods, the owner is eaten alive by one of the snakes.
A baby anaconda, which was captured at the end of the Anaconda 3: Offspring, is being used for experiment by Peter Reysner, who creates a hybrid of the blood orchids from Borneo that enabled the anaconda to grow very large and live longer, and creates a drug for cell regeneration. After the test seemingly works for the baby anaconda to regenerate, Peter burns it. When he disappears, the long anaconda escapes from the cage and kills Peter in a mine filled with blood orchids. Peter "J.D." Murdoch, a billionaire suffering from bone cancer, sends his assassin Eugene and his team of henchmen mercenaries to find Peter and the serum Peter created so that it can cure him. He also tells them to be careful of Dr. Amanda Hayes, and to kill her if needed. Dr. Amanda Hayes, the sole survivor of the previous snake attack, and two officers also go in search of Peter, determined to destroy the serum and kill the snake.
