Witness the aftermath of a mutated virus to cure rage that had the opposite effect.
A group of misguided animal rights activists free a caged chimp infected with the 'Rage' virus from a medical research lab. When London bike courier Jim wakes up from a coma a month after, he finds his city all but deserted. On the run from the zombie-like victims of the Rage, Jim stumbles upon a group of survivors, including Serena and cab driver Frank, and joins them on a perilous journey to what he hopes will be safety.
Six months after the original epidemic, the rage virus has all but annihilated the population of the British Isles. Nevertheless, the U.S. Army declares the danger past, and American soldiers arrive to restore order and begin reconstruction. Refugees return to British soil, but one of them carries a deadly secret: The virus is not gone and is even more dangerous than before.
Still living in quarantine due to the rage virus, a survivor decides to venture into the dark heart of the mainland. He soon discovers a mutation that has spread to not only the infected, but other survivors as well.
In a continuation of the epic story, Dr. Kelson finds himself in a shocking new relationship - with consequences that could change the world as they know it - and Spike's encounter with Jimmy Crystal becomes a nightmare he can't escape.