A mad scientist kidnaps and mutilates a trio of tourists in order to reassemble them into a human centipede, created by stitching their mouths to each others' rectums.
Inspired by the fictional Dr. Heiter, disturbed loner Martin dreams of creating a 12-person centipede and sets out to realize his sick fantasy.
Taking inspiration from The Human Centipede films, the warden of a notorious and troubled prison looks to create a 500-person human centipede as a solution to his problems.