Follows the misadventures of an alcoholic scientist Rick and his overly nervous grandson Morty, who split their time between domestic family life and intergalactic travel. Often finding themselves in a heap of trouble that more often than not is created through their own actions.
Rick leaves Morty at the Citadel of Ricks, and heads for Tokyo. The Citadel, under the control of Evil Morty, tell Morty that Rick is being hunted by a group called the "Genociders". They are destroying life by changing memories, with the intention that only Rick will be left at the end.
リックはマルチバース間の疑似世界でくつろぎ、サマーは銀河連邦と戦うスペース・ベスの手助けをする。そんななか、モーティは時間と無関係に生きる不思議な少女と出会い、恋に落ちる。そして、スミス家には相変わらず次々と災難が降りかかり…。