Scooby-Doo (character) and Shaggy Rogers win an all-expenses-paid stay at WWE City to watch WrestleMania after beating the hardest level of the organization's latest video game. At the insistence of the duo, Fred Jones (Scooby-Doo), Daphne Blake, and Velma Dinkley agree to join them on the trip to WWE City. Upon their arrival, the Mystery Machine crashes on a ditch after Fred narrowly avoids a crossing raccoon. The gang meets John Cena, his trainer Cookie, and Cookie's nephew Ruben before Cena lifts the Mystery Machine back on the road. They also encounter Bayard, a hunter who despises WWE for building their city in his forest. Cena gives the gang VIP tickets to the next event to make up for their altercation with Bayard.
The WWE comes to town in the new animated film teaming the Flintstones with Bedrock-ready versions of John Cena, Daniel Bryan and more.
After helping WWE solve the mystery of the ghost bear in ''Scooby-Doo! WrestleMania Mystery'', the Mystery Inc. gang is seen at WWE's latest venture, The Muscle Moto X Off Road Challenge, an off-road racecar race for WWE superstars, with a big cash prize. Scooby-Doo (character) and Shaggy Rogers are there working at a food truck. Many WWE superstars are in the race, including WWE chairman Mr. Vince McMahon's own daughter Stephanie McMahon and her husband Triple H. Scooby and Shaggy are excited to hear that The Undertaker is going to be in the race.
On present, after a live WWE show in Denver, Colorado, Big Show is scheduled to face Sheamus for the WWE Championship in Albuquerque on ''WWE SmackDown'' the next night, but Vince McMahon cancels the title match due to a snowstorm. Enraged by the cancellation, Big Show storms out of the arena and flies a plane through the blizzard only to be lost in the storm when his plane stalls.